New Study Links mRNA Vaccines to Gene Dysregulation and Cancer Risk

Researchers Call for Halt to mRNA Campaigns After Gene Study

A newly published study has ignited fierce debate in the medical community by alleging that mRNA vaccines may trigger severe, persistent disruptions in human gene expression.

Titled “Synthetic mRNA Vaccines and Transcriptomic Dysregulation: Evidence from New-Onset Adverse Events and Cancers Post-Vaccination,” the study was made available on Preprints.org in July 2025. Its lead author, Dr. John Catanzaro, represents a multidisciplinary team drawn from Nio7 Bioscience, the McCullough Foundation, the University of North Texas, and Medicinal Genomics.

This research does not merely revisit surface-level questions about short-term vaccine side effects. Instead, it dives into the molecular aftermath in patients who developed serious illnesses—including cancer—following mRNA vaccination. Using high-resolution RNA sequencing, the authors claim to have found startling biological disruptions that suggest long-term risk may be vastly underestimated.

Inside the Study Design

The researchers examined RNA profiles from three cohorts. The first included seven individuals who developed new-onset cancers within a year after receiving mRNA COVID-19 vaccines.

The second group consisted of three patients suffering from non-cancerous but serious adverse events such as cardiovascular complications and chronic fatigue. The control group, by contrast, comprised 803 healthy individuals whose blood samples were collected before the pandemic.

The team employed cutting-edge gene expression analysis tools like DESeq2 and STRING/Cytoscape to identify patterns of transcriptomic disruption. These methods allowed the researchers to map the functional relationships between thousands of genes, shedding light on hidden damage not visible through ordinary clinical tests.

What the Data Revealed

The results showed that individuals in the vaccine-injured groups exhibited massive dysregulation of thousands of genes compared to controls. According to the study, these were not random or minor deviations but included core processes responsible for maintaining healthy cellular function.

Among the most significant abnormalities was mitochondrial dysfunction. Mitochondria are the cell’s energy factories, and their impairment can lead to fatigue, neurodegeneration, and chronic disease. Alongside this, researchers identified ribosomal stress and what they called “translational overdrive,” a phenomenon they suggest is related to the synthetic nucleotides used in mRNA vaccines—particularly N1-methylpseudouridine, which is designed to increase protein translation while lowering immune recognition.

Other disruptions included proteasome activation and the buildup of misfolded proteins, which indicate long-term cellular stress and rapid ageing issues. The researchers also noted widespread endothelial dysfunction and increased blood coagulability, both of which have been linked to reports of blood clots following vaccination. Most alarming of all were changes in oncogene activation and suppression of tumor suppressor genes such as p53 and KRAS—mutations often associated with the initiation of cancer.

In the cancer group especially, the researchers found signs of genomic instability and epigenetic reprogramming. These are foundational events in tumor formation, potentially explaining how otherwise healthy individuals could develop malignancies shortly after vaccination.

Unpacking the Implications

The study’s authors do not claim to have found definitive proof that mRNA vaccines cause cancer, but they do argue that the biological signatures observed in affected individuals demand further scrutiny. One of their central concerns is that persistent spike protein expression may create ongoing stress within cells, throwing normal gene regulation into disarray.

They also raise the possibility of reverse transcription—where vaccine mRNA is copied back into DNA and integrated into the host genome. Though previously dismissed as improbable, this scenario has received more attention after some studies suggested it could occur under specific cellular conditions.

Another point of concern is the presence of plasmid DNA contaminants from the manufacturing process. These fragments could, in theory, remain in the body and interfere with normal genetic processes long after vaccination.

Chronic Immune Stress and a Call for Action

The study draws connections between these genetic disruptions and chronic inflammation—a known factor in many diseases, including cancer, autoimmune conditions, and neurodegeneration.

The researchers observed downregulation of ACE2 expression, a molecule involved in vascular and immune regulation, which they suggest could drive persistent immune activation and systemic stress.

Given the severity of these findings, the authors have urged an immediate halt to mRNA vaccine campaigns pending further investigation. They argue that the public health calculus must be reevaluated in light of these potential long-term harms and call for a return to transparent, independent review of genetic therapies.

Short-Term Changes as Well as Long-Term Risks

Pharmaceutical “experts” have responded to the study by emphasizing that gene expression changes following vaccination are typically transient and do not imply lasting damage. Indeed, numerous prior studies have shown that the immune system undergoes temporary transcriptional shifts after infection or vaccination, which may resolve as the body returns to homeostasis.

However, the authors counter that for a subset of the population—possibly those with genetic susceptibilities—these temporary changes may not resolve. Instead, they may lock in permanent dysregulation, placing individuals at heightened risk of cancer, neurological illness, or chronic immune disorders.

The question of individual vulnerability remains unresolved. While N1-methylpseudouridine may enhance vaccine performance in most people, it could simultaneously disrupt cellular signaling in others. Without broader long-term data, the safety profile for genetically modified RNA remains uncertain.

New Concerns About Pet Shedding

Another area of scrutiny involves the concept of “shedding”—the idea that vaccinated individuals or animals could pass along biologically active components, such as spike proteins, to others.

While no pharmaceutical company studies currently admit significant shedding from mRNA vaccines, it remains a topic of interest for those tracking unexplained adverse events among close contacts of vaccine recipients.

The new study also points out the lack of independent safety data for veterinary mRNA products. For example, Merck’s Nobivac NXT for animals has been approved with minimal transparency about long-term risk, gene transfer potential, or environmental contamination. If similar genomic dysregulation occurs in animals, it could raise both ethical and ecological questions about the future of veterinary genetic therapies.

An Urgent Need for Independent Oversight

Whether these findings withstand future peer review or not, the new preprint underscores the pressing need for rigorous, independent evaluation of mRNA vaccine safety. The technology is still in its infancy, and its rollout has far outpaced the depth of our understanding.

For the millions who have received mRNA vaccines, the study does not offer immediate answers—but it does offer a serious reason to press for more transparency, accountability, and extreme caution.

Until these questions are resolved through honest inquiry and open scientific dialogue, trust in genetic medicine will remain as fragile as the molecules it seeks to engineer.

Source: https://www.offthegridnews.com/what-they-dont-want-you-to-know/new-study-links-mrna-vaccines-to-gene-dysregulation-and-cancer-risk/