COVID and flu vaccines could soon come in dental floss form
COVID and flu vaccines could soon come in dental floss form
Vaccines given via dental floss could one day allow people to immunize themselves from COVID in the comfort of their own homes without having to use needles.
This is the finding of North Carolina (NC) State University researchers who have demonstrated the new delivery method in an animal model—introducing a flu vaccine via the tissue between the teeth and gums.
The novel approach has potential for broad application, the team says.
“We expect the approach to work with COVID vaccine that uses mRNA, hepatitis and tetanus since they use subunit proteins as antigens, and other vaccines that use inactivated or attenuated viruses as antigens (such as MMR vaccine),” paper author and NC State nanomedicine professor Harvinder Singh Gill told Newsweek.
“In essence through proper formulation of the coating, the approach should work with any vaccine.”
The researchers discovered the new method stimulates the production of antibodies in mucosal surfaces—the moist linings of various body cavities— like the nose and lungs.
“Mucosal surfaces are important, because they are a source of entry for pathogens, such as influenza and COVID,” Gill said in a statement.
“However, if a vaccine is given by injection, antibodies are primarily produced in the bloodstream throughout the body, and relatively few antibodies are produced on mucosal surfaces.
“But we know that when a vaccine is given via the mucosal surface, antibodies are stimulated not only in the bloodstream, but also on mucosal surfaces.
“This improves the body’s ability to prevent infection, because there is an additional line of antibody defense before a pathogen enters the body.”
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