DOOM -- Scientists Grow Mini Brains in a Lab and teach them to play Video Games

DOOM — Scientists Grow Mini Brains in a Lab and teach them to play Video Games
https://youtu.be/Sl29QRhiZtQ

Scientists Grow Mini Brains in a Lab and teach them to play video games like Doom and Pong. Scientists also grow these miniature brains in Space at the International Space Station. The term used is Organoids. Scientists also grow multiple organoids and connect them to each other and refer to them as assembloids. Buck Rodgers meets Hellraiser! Halo

Articles for reference below

Scientists create brains on a chip to play video games
https://www.iflscience.com/they-are-learning-cortical-labs-makes-200000-living-human-brain-cells-play-doom-82732

Mini Brains Grown in Space
https://issnationallab.org/iss360/brain-cell-research-published-marotta/

Assembloids
https://www.nature.com/articles/s41586-024-08487-6

Brain Cells Learning Pong (DishBrain Experiment)

Primary research paper (Neuron Journal)

https://www.cell.com/neuron/fulltext/S0896-6273(22)00806-6

This is the peer-reviewed paper describing the DishBrain experiment where neurons grown in a dish learned to play Pong.

Monash University research announcement

https://www.monash.edu/medicine/news/latest/2022-articles/brain-cells-in-a-dish-learn-to-play-pong

Explains how about 800,000 neurons grown on electrodes learned the game Pong through electrical feedback signals.

Scientific American coverage

https://www.scientificamerican.com/article/neurons-in-a-dish-learn-to-play-pong/

Detailed explanation of the DishBrain experiment and how neurons adapted to the game environment.

NPR / NIH research summary

https://www.ncbi.nlm.nih.gov/search/research-news/17391

Overview of how scientists connected neurons to a simulated game environment.

Biological Computers With Living Neurons

Live Science article on the first biological computer

https://www.livescience.com/technology/computing/worlds-1st-computer-that-combines-human-brain-with-silicon-now-available

Describes the CL1 biological computer developed by Cortical Labs, which integrates human neurons with silicon chips.

Brain Cells Playing DOOM

Tom’s Hardware coverage

https://www.tomshardware.com/tech-industry/artificial-intelligence/200-000-living-human-neurons-on-a-microchip-demonstrated-playing-doom-cortical-labs-cl1-video-shows-the-gameplay-and-explains-how-the-neurons-learn-the-game

Shows how 200,000 neurons on a chip were used to control gameplay in DOOM through electrical stimulation and feedback.

News.com coverage

https://www.news.com.au/technology/online/internet/researchers-teach-biological-computer-made-from-human-brain-cells-to-play-doom/news-story/f2675888f462dd9d5f8e81becdb46fd2

Explains how biological neural networks can interact with video game environments.

Brain Organoids Producing Brainwaves

UC San Diego research coverage

https://today.ucsd.edu/story/lab-grown-brain-organoids-produce-brain-waves

Scientists discovered that mini brains grown from stem cells produced electrical patterns similar to premature infants.

Nature coverage of the study

https://www.nature.com/articles/d41586-019-02593-2

Explains the significance of brainwave activity observed in organoids.

Brain Organoids Growing Eye Structures

Science Alert coverage

https://www.sciencealert.com/lab-grown-mini-brains-have-developed-eyelike-structures-for-the-first-time

Researchers discovered optic cup structures forming in brain organoids.

Cell Stem Cell research paper

https://www.cell.com/cell-stem-cell/fulltext/S1934-5909(21)00354-4

Describes how brain organoids developed retina-like structures capable of responding to light.

Brain Organoids Sent to Space (ISS Experiments)

Cedars-Sinai / NASA research

https://www.cedars-sinai.org/newsroom/stem-cells-growing-mini-brains-in-space

Researchers sent brain organoids to the International Space Station to study how microgravity affects brain development.

NASA biological experiment overview

https://www.nasa.gov/mission_pages/station/research/news/brain-organoids-space

Discusses how organoids can grow differently in microgravity environments.

Medium article reference

https://medium.com/@JacksonAAaron/scientists-taught-brain-organoids-to-play-doom-d16f803412f2

Overview explaining how neuron cultures connected to computers can interact with video game environments.