Large Study Shows High Caffeine Intake Linked To Reduced Dementia Risk

Authored by George Citroner via The Epoch Times (emphasis ours),

A daily cup of coffee or tea may do more than wake you up – it could also help keep your brain sharp as you age.

Coffee, like this?

New research tracking hundreds of thousands of people over decades suggests that moderate caffeine consumption is linked to a lower risk of developing dementia.

Wang and his team tracked participants from two long-term studies of medical professionals, the Nurses’ Health Study and Health Professionals Follow-Up Study, with starting ages typically in their mid-40s to early 50s.

They found that people who drank between one and five eight-ounce cups of caffeinated coffee had an 18 percent reduced risk of dementia. However, those who drank caffeinated tea daily had a roughly 15 percent reduced risk.

Interestingly, the benefits plateaued beyond two and a half cups of coffee daily, possibly because the body cannot process higher amounts of the beneficial compounds in these beverages. Caffeine can mimic adenosine and bind to receptors in the brain, blocking the molecule that promotes sleepiness, and keeping us alert, Knight said. By doing so, it increases neuron activity, which may reduce inflammation.

“Inflammation is being studied as a cause of cognitive impairment,” she said. “Caffeine has the potential to reduce oxidative stress and neuroinflammation, which helps to decrease brain aging.”

The study also looked at subjective cognitive decline—people’s perceptions that their memory and thinking skills are slipping. Those who drank more caffeine were less likely to report such issues. Among women over 70, those who drank more caffeine scored better on cognitive tests, indicating slower cognitive decline by about seven months.

Cognitive decline was assessed using cohort-specific questionnaires with yes-or-no responses covering general memory, executive function, attention, and visuospatial skills.

The better cognition among tea and coffee drinkers may come from caffeine’s ability to increase dopamine and acetylcholine in the brain, which are important for memory and cognition, Knight said. “Dopamine is the reward center in the brain and leads to feeling alert, focused, and pleasure. Acetylcholine is the memory neurotransmitter.”

Researchers caution that they cannot determine causation and that other factors may influence the results. For example, some participants might have been drinking decaffeinated coffee for health reasons, which could affect outcomes.

Coffee acts as a diuretic, which can lead to dehydration—a concern given that most adults already fall short of the recommended eight glasses of water a day.

“I always tell my patients for each cup of coffee you should drink a glass of water.” She added that dehydration can lead to altered mental status, confusion, and kidney damage.

Finally, Knight cautioned that older people should be careful about caffeine intake, because it can disrupt sleep, which itself is a risk factor for cognitive decline.

“Caffeine can lead to increased difficulty with sleep,” she said. “Poor sleep can impair cognition, causing increased confusion or brain fog, and increase dementia risk over time.”