Researchers develop graphene oxide hybrid electrodes for real-time dopamine monitoring
Researchers at Sungkyunkwan University (SKKU), Hong Kong University of Science and Technology (HKUST) and Jeonbuk University have developed a graphene oxide–wrapped hybrid electrode platform that allows real-time, label-free monitoring of dopamine activity from living neuronal cells and brain organoids. The innovation, named SIDNEY (Smart Interfacial Dopamine-sensing platform for NEurons and organoid physiologY), addresses a long-standing challenge in neuroscience: how to measure functional maturation of stem-cell-derived dopaminergic neurons without destroying the sample.
Built around a hierarchical nanostructure of vertically aligned gold nanopillars adorned with smaller gold nanoparticles and encased in a thin graphene oxide layer, SIDNEY forms a high-conductivity, high-selectivity interface that supports long-term cell culture and differentiation. The graphene oxide coating plays a crucial role – its aromatic carbon rings engage in π–π stacking while negatively charged carboxyl groups attract dopamine’s positively charged amine moiety, ensuring selective capture and efficient electron transfer.
Source: https://www.graphene-info.com/researchers-develop-graphene-oxide-hybrid-electrodes-real-time-dopamine
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