German E. coli Outbreak sickens 255
As of October 2025, the German Robert Koch Institute (RKI) and public health officials have confirmed an E. coli O45:H2 outbreak that has sickened hundreds of people. The outbreak originated in the Mecklenburg-Western Pomerania region in August and later spread to Nordrhein-Westfalen.
Key details of the outbreak:
• Case numbers: As of early October, there were 255 total cases linked to the outbreak, including 137 confirmed infections. A BioExpert news report on October 25 updated the total to 351 illnesses.
• Confirmed strain: The RKI’s National Reference Center identified the cause as E. coli O45:H2, a rare serotype in Germany. The strain possesses genes that produce Shiga toxin, making it particularly dangerous.
• Impact on children: Children are disproportionately affected. In mid-September, the median age of confirmed cases was 4 years old. Earlier reports in late August noted that 14 children aged 1 to 12 were among the initial cases.
• HUS cases: Many patients have developed hemolytic uremic syndrome (HUS), a severe complication that can lead to kidney failure and brain damage. In early October, 38 confirmed cases had progressed to HUS.
• Deaths: One probable death in a person over 90 has been reported, but it lacked laboratory confirmation. On October 25, a different source reported three deaths attributed to the outbreak.
• Source remains unknown: As of October 2025, the exact source of contamination has not been identified. Officials suspect a contaminated food product that is widely distributed.
• Investigation methods: The RKI is conducting case-control studies, surveying patients by phone, and analyzing shopping receipts to determine the source of the infection.
Republished with permission from Bill Marler and Marler Clark. Copyright (c) Marler Clark LLP, PS. All rights reserved.
Source: https://www.marlerblog.com/case-news/german-e-coli-outbreak-sickens-255/
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